5-amino-1mq 5mg
Products will arrive in a lyophilized (powder) form for maximum stability
$40.00
5-Amino-1MQ (NNMT Inhibitor)
Premium Research Compound for Metabolic & Longevity Studies
Product Overview
5-Amino-1MQ (5-amino-1-methylquinolinium) is a small-molecule drug candidate that has emerged as a potent and selective inhibitor of Nicotinamide N-Methyltransferase (NNMT).1 NNMT is a cytosolic enzyme responsible for catalyzing the methylation of nicotinamide (NAM) into 1-methylnicotinamide (1-MNA) using S-adenosylmethionine (SAM) as a methyl donor.2
By inhibiting NNMT activity, 5-Amino-1MQ disrupts this pathway, leading to a downstream increase in intracellular NAD⁺ (Nicotinamide Adenine Dinucleotide) availability.3 This mechanism makes 5-Amino-1MQ a critical tool for researchers investigating mitochondrial function, metabolic efficiency, sirtuin activation, and cellular aging processes.
At 4Balance Peptides, we supply research-grade 5-Amino-1MQ tested to ≥98% purity via HPLC and mass spectrometry, ensuring consistency for demanding experimental protocols.
Primary Research Mechanisms & Applications
1. Metabolic Regulation & Adipose Physiology
NNMT expression is often upregulated in adipose tissue during obesity.4 5-Amino-1MQ is utilized in models exploring energy expenditure and fat tissue plasticity.5
Adipocyte Browning: Research indicates that NNMT inhibition promotes the "browning" of white adipose tissue (WAT) into metabolically active beige/brown adipose tissue (BAT), thereby increasing thermogenesis and whole-body energy expenditure (Neelakantan et al., 2019).
Lipid Metabolism: In hepatocyte models, 5-Amino-1MQ has been shown to enhance fatty acid oxidation and reduce lipid accumulation, suggesting utility in non-alcoholic fatty liver disease (NAFLD) research (Jung et al., 2021).
Metabolic Health: Studies in obese murine models demonstrate that 5-Amino-1MQ administration increases NAD⁺ levels and improves overall metabolic health parameters (Kraus et al., 2018).
2. Anti-Aging and NAD⁺ Restoration Pathways
NAD⁺ levels naturally decline with age, contributing to mitochondrial dysfunction and cellular senescence.6 5-Amino-1MQ is a key compound in longevity research aimed at restoring NAD⁺ homeostasis.7
Sirtuin Activation: By boosting NAD⁺ levels, NNMT inhibition supports the activity of sirtuins (NAD⁺-dependent deacetylases), which are critical regulators of cellular stress resistance and longevity (Pissios et al., 2020).
Mitochondrial Biogenesis: Preclinical models link NNMT inhibition to improved ATP production, reduced oxidative stress, and enhanced mitochondrial biogenesis, counteracting age-related metabolic decline (Ryu et al., 2022).
Cellular Senescence: In fibroblast culture systems, 5-Amino-1MQ has demonstrated the ability to delay markers of cellular aging (Lee et al., 2023).
3. Neuroprotection & Cognitive Function
The brain is highly dependent on energy metabolism.8 Emerging research suggests 5-Amino-1MQ may offer neuroprotective benefits by supporting neuronal energetics.9
Neuronal NAD⁺: By supporting neuronal NAD⁺ levels, 5-Amino-1MQ may improve mitochondrial function and neuronal resilience against stress (Zhang et al., 2021).
Neurodegenerative Models: Studies in Alzheimer’s disease models have shown protective effects against amyloid-beta toxicity following NNMT inhibition (Chen et al., 2023).
Cognitive Performance: Administration of 5-Amino-1MQ has been associated with improved memory performance in aged rodent models (Wilson et al., 2023).
Technical Specifications & Handling
Compound: 5-Amino-1MQ (5-amino-1-methylquinolinium)
Purity: ≥98% (verified by HPLC/MS)
Format: Lyophilized powder for enhanced stability.
Storage: Store at –20°C for long-term stability. Protect from light and moisture.
Reconstitution: Soluble in DMSO or suitable sterile vehicles (e.g., saline) depending on the experimental design (in vitro vs. in vivo). Avoid repeated freeze–thaw cycles; aliquot after initial reconstitution.
Research Protocol Guidelines (Suggested)
For laboratory research use in controlled settings only. Not for human or veterinary administration.
The following dosages are sourced from published literature and should be optimized by the researcher based on the specific model and study duration.
Research Model | Suggested Dosage Range | Administration Route |
In Vitro Studies | 1–10 µM | Cell culture media |
Animal Models (Mice) | 5–20 mg/kg | Oral or IP injection |
Chronic Metabolic Studies | 10–30 mg/kg | Oral gavage |
Why Choose 4Balance Peptides?
We are committed to supporting high-quality, reproducible science by providing researchers with premium compounds.
✔ Purity Guaranteed: ≥98% HPLC-verified.
✔ Analytical Confirmation: Identity verified via Mass Spectrometry.
✔ Reliable Logistics: Prompt USA shipping with appropriate packaging.
Disclaimer
This product is sold exclusively for laboratory research purposes. It is NOT intended for human consumption, medical treatment, diagnostic use, or veterinary administration. By purchasing 5-Amino-1MQ from 4Balance Peptides, you affirm that you are a qualified researcher, equipped to handle experimental compounds, and will use this product in compliance with all applicable local, state, and institutional regulations.
