5-Amino-1MQ

Available in 50mg Tablets (25 Count Bottle)

The Metabolic Enzyme Inhibitor | NNMT Blockade & Cellular NAD+ Restorer

The 4Balance Codex: The Cellular Energy Shift. A potent, membrane-permeable small molecule that acts as a selective inhibitor of the NNMT enzyme. By preventing the enzymatic "wastage" of nicotinamide in adipose tissue, it forces substrate back into the salvage pathway, restoring intracellular NAD+ levels and driving metabolic efficiency from within the fat cell.

Product Overview

5-Amino-1MQ represents a significant departure from traditional metabolic research agents. It is not a stimulant, appetite suppressant, or thermogenic agent in the conventional sense. It is a targeted enzyme inhibitor designed to address a fundamental metabolic flaw often observed in obesity and aging: the overactivation of the enzyme nicotinamide N-methyltransferase (NNMT).

Research indicates that elevated NNMT activity in fat tissue is a key driver of metabolic inefficiency. 5-Amino-1MQ is engineered to correct this cellular imbalance. 4Balance Peptides offers this sophisticated research compound in high-concentration 50mg tablets, providing precise dosing control for advanced metabolic investigations.

Mechanism of Action: The NAD+ Salvage Pathway Rescue

The value of 5-Amino-1MQ in research stems from its ability to intervene in the cellular "NAD+ Salvage Pathway" within white adipose tissue (WAT):

1. The Problem (NNMT Overactivation): The enzyme NNMT is highly expressed in adipose tissue, particularly in states of obesity. NNMT takes nicotinamide (a precursor to NAD+) and adds a methyl group to it, creating 1-methylnicotinamide (MNA). This process essentially "wastes" nicotinamide, preventing it from being used to create cellular energy, and simultaneously depletes the body's methyl donor pool (SAM).

2. The Intervention (NNMT Inhibition): 5-Amino-1MQ binds to and inhibits NNMT. This blockade stops the conversion of useful nicotinamide into inert MNA.

3. The Result (NAD+ Restoration): By blocking the "drain," 5-Amino-1MQ forces nicotinamide back into the salvage pathway. This directly leads to significantly increased intracellular levels of NAD+ (Nicotinamide Adenine Dinucleotide).

4. Metabolic Shift: NAD+ is the critical coenzyme for mitochondrial energy production (ATP). By restoring NAD+ specifically within fat cells, research models have demonstrated a shift in adipocyte physiology—shrinking white fat cell size, increasing their metabolic rate, and improving overall energy expenditure without altering food intake or causing CNS stimulation.

Primary Research Applications

In the 4Balance Research Array, 5-Amino-1MQ is a premier agent for studies focused on correcting cellular metabolic defects:

• Obesity & Adipose Tissue Remodeling: Investigating the mechanisms of shrinking white adipocyte size and reversing diet-induced obesity independent of caloric restriction.

• NAD+ Physiology & Aging: Studying targeted methods of boosting cellular NAD+ specifically in metabolic tissues, distinct from systemic precursor supplementation (like NR or NMN).

• Type 2 Diabetes & Insulin Resistance: Researching the downstream effects of NNMT inhibition on improving glucose tolerance and insulin sensitivity.

• Skeletal Muscle Function: Emerging research suggests NNMT inhibition may also play a role in improving muscle recovery and satellite cell function via NAD+ dependent pathways.

Technical Specifications

• Compound Name: 5-Amino-1MQ (5-amino-1-methylquinolin-1-ium)

• Format: Oral Tablets

• Concentration: 50mg per Tablet

• Quantity: 25 Tablets

• Purity: ≥99% (HPLC Verified)

• Mechanism: Selective NNMT Inhibitor

• Storage: Store at room temperature, away from direct light and moisture.

DISCLAIMER: FOR LABORATORY RESEARCH USE ONLY. This product is a laboratory chemical intended strictly for in-vitro and in-vivo research and development. It is not a drug, dietary supplement, or treatment for any medical condition. NOT for human consumption, veterinary use, or therapeutic application. Bodily introduction of any kind is strictly prohibited by law. Buyer assumes all responsibility for applicable regulations and appropriate use in a research setting.