NAD+ (Nicotinamide Adenine Dinucleotide)

Available in 100mg & 500mg Lyophilized Vials

The Cellular Battery | The Universal Coenzyme

The 4Balance Codex: The Fundamental Substrate. Fueling Mitochondrial ATP Production, DNA Repair, and Sirtuin Activation.

Product Overview

NAD+ (Nicotinamide Adenine Dinucleotide) is a coenzyme found in every living cell. It is arguably the most critical molecule for sustaining life beyond the genetic code itself. NAD+ serves two distinct functions: it acts as a carrier of electrons in metabolic reactions and as a consumable substrate for signaling enzymes.

We offer this essential research compound in two formats:

• 100mg Vial: Ideal for precise, single-assay pilots or titration experiments.

• 500mg Vial: A high-capacity format designed for intensive dosing protocols or the preparation of substantial stock solutions.

Mechanism of Action: The Tri-Fold Function

NAD+ is the pivot point for three major physiological pathways. Research indicates that NAD+ levels naturally decline with age, making its supplementation a primary focus of longevity science.

1. Mitochondrial ATP Production (The Fuel): In the Electron Transport Chain, NAD+ accepts electrons to become NADH. This redox cycling is the driving force behind the production of ATP (cellular energy). Without sufficient NAD+, mitochondrial energy output collapses.

2. Sirtuin Activation (The Longevity Switch): Sirtuins (SIRT1–SIRT7) are a family of proteins that regulate cellular health, aging, and inflammation. However, Sirtuins are NAD+-dependent—they cannot function without NAD+ as a fuel source.

3. DNA Repair (PARP Pathway): PARPs are enzymes that detect and repair DNA damage. They require NAD+ to function. Under high stress or radiation, PARPs consume massive amounts of NAD+, which can deplete cellular energy reserves if not replenished.

Primary Research Applications

In the 4Balance Research Array, NAD+ is the foundational compound for metabolic and geriatric research:

• Mitochondrial Biogenesis: Investigating the restoration of efficient energy production in aged or metabolically compromised cells.

• Longevity & Anti-Aging: Studying the activation of Sirtuins to mimic the effects of caloric restriction and extend healthspan.

• Neuroprotection: Researching the ability of NAD+ to protect neurons from oxidative stress and support cognitive function in models of neurodegeneration.

• Addiction & Recovery: Investigating the role of NAD+ in replenishing neurotransmitter balance and reducing withdrawal symptoms in dependency models.

Technical Specifications

• Compound Name: β-Nicotinamide Adenine Dinucleotide (Oxidized Form)

• Abbreviation: NAD+

• Chemical Formula: C₂₁H₂₇N₇O₁₄P₂

• Available Sizes: 100mg / 500mg

• Format: Lyophilized Powder (White to off-white)

• Purity: ≥98% (HPLC Verified)

• Solubility: Highly Water Soluble.

• Storage: Store lyophilized at -20°C. Note: NAD+ is hygroscopic (absorbs moisture from air). Keep vials tightly sealed.

DISCLAIMER: FOR LABORATORY RESEARCH USE ONLY. This product is a laboratory reagent intended strictly for in-vitro and in-vivo research and development. It is not a drug, dietary supplement, or treatment for any medical condition. NOT for human consumption, veterinary use, or therapeutic application (e.g., IV infusions for humans). Bodily introduction of any kind is strictly prohibited by law. Buyer assumes all responsibility for applicable regulations and appropriate use in a research setting.