Here is a product description for AOD-9604 designed for the 4Balance Peptides store, maintaining the professional, research-oriented tone of your previous items.

AOD-9604 5mg Vial

For Laboratory Research Use Only. Not For Human Consumption.

Product Overview

AOD-9604 (Advanced Obesity Drug) is a synthetic peptide analog of the C-terminal fragment of human growth hormone (hGH), specifically consisting of amino acids 177-191 with an added tyrosine residue at the N-terminus for stability.

Originally developed to isolate the fat-burning (lipolytic) characteristics of growth hormone without its growth-promoting (anabolic) and insulin-modulating effects, AOD-9604 has become a primary subject of metabolic research. Unlike full-length hGH, AOD-9604 does not bind to the hGH receptor, meaning it does not stimulate the release of Insulin-like Growth Factor 1 (IGF-1) or negatively impact blood sugar regulation, making it a highly specific tool for investigating lipid metabolism and cartilage repair.

Mechanism of Action

Research has established that AOD-9604 mimics the lipolytic domain of hGH, functioning through a distinct dual pathway:

1. Stimulation of Lipolysis: It triggers the breakdown of stored fat (triglycerides) into free fatty acids and glycerol.

2. Inhibition of Lipogenesis: It prevents the transformation of non-fatty food materials into body fat.

Beta-3 Adrenergic Interaction: While AOD-9604 does not bind directly to beta-3 adrenergic receptors (like many stimulants), studies indicate it upregulates the expression of these receptors in adipose tissue. This modulation sensitizes the fat cells to lipolytic signals, specifically targeting visceral and abdominal fat depots, which typically have a higher density of these receptors.

Research-Observed Benefits

In controlled laboratory and clinical studies, AOD-9604 has been associated with several specific physiological outcomes:

• Targeted Adipose Reduction: Promotes fat loss specifically in the mid-abdominal and visceral regions in animal models.

• Cartilage Regeneration: When combined with Hyaluronic Acid (HA), AOD-9604 has been shown to enhance the differentiation of mesenchymal stem cells into chondrocytes, supporting cartilage repair in osteoarthritis models.

• Metabolic Flexibility: Enhances energy expenditure and fat oxidation without altering blood glucose or insulin sensitivity.

• Muscle Recovery: Preliminary research suggests potential benefits in soft tissue repair, likely linked to its regenerative cellular signaling.

Key Research Findings

• Obesity & Fat Oxidation: A foundational study by Heffernan et al. (2001) demonstrated that chronic administration of AOD-9604 in obese mice reduced body weight gain and increased lipolytic sensitivity, effectively matching the fat-loss potential of hGH without the associated hyperglycemia.

• Human Safety Data: A comprehensive safety review by Stier et al. (2013), covering six human clinical trials, found that AOD-9604 possessed a safety profile indistinguishable from placebo. Critically, it did not induce anti-peptide antibodies or elevate IGF-1 levels, confirming its non-growth-promoting nature.

• Osteoarthritis & Repair: Research published in Annals of Clinical & Laboratory Science (2015) indicated that intra-articular injections of AOD-9604 combined with HA significantly improved cartilage regeneration and reduced lameness in rabbit models of collagenase-induced knee osteoarthritis.

Safety and Side Effects in Research

AOD-9604 is noted for its exceptional safety profile in research literature compared to traditional metabolic agents. Because it lacks affinity for the hGH receptor, it avoids common hGH side effects like water retention, joint pain (arthralgia), and insulin resistance.

• Adverse Events: In clinical settings, side effects were rare and comparable to placebo, occasionally including mild injection site reactions or transient headache.

• IGF-1 Neutral: Does not increase IGF-1, eliminating cancer-proliferation concerns often associated with long-term growth hormone research.

Product Specifications

• Product Name: AOD-9604 (Tyr-hGH Frag 177-191)

• Sequence: Tyr-Leu-Arg-Ile-Vla-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe

• CAS Number: 221231-10-3

• Format: Lyophilized Powder (Vial)

• Concentration: 5mg per vial

• Purity: >99% (HPLC Verified)

• Solubility: Water-soluble (Requires Reconstitution)

• Storage: Store at -20°C for long-term stability. Store away from direct sunlight.

Important Research Note: This product is sold strictly for laboratory research purposes only. It is not approved by the FDA for human consumption. AOD-9604 is not a dietary supplement, food, or drug.

Disclaimer: This product is intended solely for research purposes. It is not intended for human consumption, medical treatment, or therapeutic use. Buyer assumes all responsibility for applicable regulations and appropriate use in a research setting.

Scientific References:

1. Heffernan, M., et al. (2001). The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice and beta-3-AR knock-out mice. Endocrinology.

2. Ng, F. M., et al. (2000). Metabolic studies of a synthetic lipolytic domain (AOD9604) of human growth hormone. Hormone Research.

3. Stier, H., et al. (2013). Safety and Tolerability of the Hexadecapeptide AOD9604 in Humans. Journal of Endocrinology and Metabolism.

4. Kwon, D. R., & Park, G. Y. (2015). Effect of Intra-articular Injection of AOD9604 with or without Hyaluronic Acid in Rabbit Osteoarthritis Model. Annals of Clinical & Laboratory Science.