Cerebrolysin (60mg)

Porcine Brain-Derived Peptide Complex | Neurotrophic Factor Mimetic

The 4Balance Codex: The Architect of Neural Repair and Synaptic Plasticity.

Product Overview

Cerebrolysin is a multimodal neuropeptide preparation consisting of low-molecular-weight peptides (<10 kDa) and free amino acids derived from purified porcine brain tissue. Unlike single-molecule agents, this complex provides a "scaffold" of neurotrophic support that mimics the action of endogenous growth factors. In the research setting, it is the gold standard for investigating neuroprotection, neurogenesis, and the restoration of the Blood-Brain Barrier (BBB) following ischemic or traumatic insult.

Format: 60mg Lyophilized Powder Source: Porcine Brain Hydrolysate (Standardized) Active Components: Mimics of BDNF, NGF, GDNF, and CNTF

Mechanism of Action: The Sonic Hedgehog & PI3K Pathways

Cerebrolysin functions not just by protecting neurons, but by actively signaling for their repair through primitive developmental pathways.

1. Sonic Hedgehog (Shh) Activation: Research demonstrates that Cerebrolysin upregulates the Sonic Hedgehog signaling pathway. This activation triggers the expression of genes responsible for neurogenesis (birth of new neurons) and oligodendrogenesis (repair of myelin sheaths), effectively reopening a "therapeutic window" for brain repair typically found only in development.

2. Neurotrophic Mimicry: The peptide complex acts as a functional analogue to Brain-Derived Neurotrophic Factor (BDNF) and Nerve Growth Factor (NGF). By binding to TrkB receptors, it activates the PI3K/Akt signaling cascade, which inhibits apoptotic (cell death) enzymes and promotes cell survival.

3. Amyloid Regulation: In models of neurodegeneration, Cerebrolysin has been observed to reduce the phosphorylation of Amyloid Precursor Protein (APP), thereby decreasing the production of the toxic beta-amyloid plaques associated with Alzheimer's pathology.

Research Applications

In the 4Balance Research Array, Cerebrolysin (60mg) is utilized to study the structural integrity of the central nervous system.

• Traumatic Brain Injury (TBI): Studies indicate that early administration can significantly reduce the leakage of proteins across the Blood-Brain Barrier (BBB) and mitigate brain edema (swelling) following impact.

• Stroke & Ischemia: It is widely researched for its ability to stimulate "axonal sprouting" and the recruitment of new neuronal networks to bypass damaged tissue (neuroplasticity).

• Small Fiber Neuropathy: Through the modulation of NGF/pro-NGF ratios, it supports the survival of cholinergic neurons and may restore nerve fiber density.

Codex Note: Because the peptides are low molecular weight (<10k Daltons), they are small enough to cross the Blood-Brain Barrier effortlessly, unlike larger synthetic proteins.

Technical Specifications

• Mass: 60mg (Lyophilized Peptide Fraction)

• Origin: Porcine (Pig) Brain Hydrolysate

• Solubility: Water Soluble (Requires Bacteriostatic Water or Sterile Saline)

• Stability: Stable at room temperature as a lyophilized powder. Once reconstituted, the solution is highly sensitive to enzymatic degradation and should be used immediately or refrigerated for no more than 24 hours.

References

1. Zhang, L., et al. (2013). Sonic hedgehog signaling pathway mediates cerebrolysin-improved neurological function after stroke. Stroke.

2. Chen, H., et al. (2007). Trophic factors counteract elevated FGF-2-induced inhibition of adult neurogenesis. Neurobiology of Aging.

3. Sharma, A., et al. (2010). Cerebrolysin reduces blood-cerebrospinal fluid barrier permeability change, brain pathology, and functional deficits following traumatic brain injury in the rat. Annals of the New York Academy of Sciences.

4. Muresanu, D. F., et al. (2016). Cerebrolysin and Recovery after Stroke (CARS): A Randomized, Placebo-Controlled, Double-Blind, Multicenter Trial. Stroke.

5. Rockenstein, E., et al. (2006). Cerebrolysin decreases amyloid-beta production by regulating amyloid protein precursor maturation in a transgenic model of Alzheimer's disease. Journal of Neuroscience Research.

DISCLAIMER: FOR RESEARCH USE ONLY. This product is a laboratory reagent intended strictly for in-vitro research and development. It is not for human consumption, veterinary use, or therapeutic application. Bodily introduction of any kind is strictly prohibited by law.