CJC-1295 No DAC (Modified GRF 1-29)
High Purity Peptide — 5mg & 10mg
$60.00
CJC-1295 No DAC (Modified GRF 1-29)
Available in 5mg & 10mg Lyophilized Vials
Short-Acting GHRH Secretagogue | The "Pulsatile" Agent
The 4Balance Codex: The Architect of Physiological, Pulsatile Growth Hormone Dynamics.
Product Overview
CJC-1295 No DAC, frequently cited in literature as Modified GRF 1-29, is a synthetic, tetrasubstituted 29-amino acid analogue of endogenous Growth Hormone-Releasing Hormone (GHRH).
This peptide is distinguished by the absence of the "Drug Affinity Complex" (DAC) linker found in its long-acting counterpart. Without the DAC tail to bind serum albumin, this analogue possesses a significantly shorter half-life (~30 minutes in research models).
CJC-1295 No DAC is the premier research tool for investigators seeking to replicate physiological, pulsatile Growth Hormone (GH) secretion patterns, avoiding the chronic, continuous elevation associated with long-acting agents. We offer this essential research compound in both 5mg and 10mg formats to suit various experimental scales.
Mechanism of Action: Engineered Stability & Natural Rhythm
CJC-1295 No DAC is designed to overcome the rapid degradation of native GHRH while maintaining a natural secretory profile.
Enhanced Enzymatic Stability (The "Modified" Aspect): Native GHRH (1-29) is rapidly degraded by the enzyme dipeptidyl peptidase-IV (DPP-IV). CJC-1295 No DAC incorporates four strategic amino acid substitutions (D-Ala2, Gln8, Ala15, Leu27). These modifications render it highly resistant to DPP-IV cleavage, significantly increasing its in vivo bioactivity compared to unmodified Sermorelin.
Mimicry of Endogenous Rhythms (The "No DAC" Aspect): By lacking the albumin-binding DAC tail, this peptide prevents a long-term "GH bleed." Instead, it allows researchers to stimulate distinct peaks of GH followed by necessary troughs. This mimics the body's natural circadian and ultradian rhythms, a crucial factor for maintaining pituitary receptor sensitivity and avoiding tachyphylaxis (desensitization).
Selective GHRH Receptor Agonism: The peptide binds specifically to the GHRH receptor (GHRH-R) in the anterior pituitary gland, triggering cAMP signaling to release stored growth hormone in a distinct pulse.
Primary Research Applications
In the 4Balance Research Array, CJC-1295 No DAC is the preferred agent for studies requiring precise temporal control over GH release.
Physiological GH Dynamics: Used to model natural, spike-dependent GH signaling and its downstream effects on IGF-1 levels, lipolysis, and protein synthesis without causing pituitary desensitization.
Synergistic Secretagogue Studies: Frequently utilized in combination protocols with Ghrelin mimetics (GHRPs such as Ipamorelin or GHRP-6) to investigate the synergistic amplification of pituitary GH output via simultaneous activation of distinct enzymatic pathways.
Sleep Architecture & Circadian Rhythm: Because endogenous GH secretion peaks during slow-wave sleep, the short half-life of this compound makes it ideal for sleep-related endocrine research protocols.
Technical Specifications
Format: Lyophilized Powder
Options: Available in 5mg or 10mg vials
Sequence Length: 29 Amino Acids (Tetrasubstituted modification)
Molecular Formula: C₁₅₂H₂₄₃N₄₇O₄₂
Molecular Weight: 3367.9 g/mol
Solubility: Water Soluble (Requires Bacteriostatic Water for reconstitution)
Storage: Store lyophilized at -20°C. Reconstituted peptide should be kept at 4°C and used within established research timelines to maintain peak bioactivity.
Key References
Campbell, R. M., et al. (1996). ORG 2766 and GRF analogs: peptide mediators of nerve regeneration and GH release. Peptides.
Jetté, L., et al. (2005). Human Growth Hormone-Releasing Factor (hGRF)1–29-Albumin Bioconjugates Activate the GRF Receptor on the Anterior Pituitary in Rats: Identification of CJC-1295 as a Long-Lasting hGRF Analog. Endocrinology.
Note on comparative literature: Teichman, S. L., et al. (2006) in The Journal of Clinical Endocrinology & Metabolism describes the DAC version, establishing the baseline for understanding why the "No DAC" version behaves differently regarding half-life.
DISCLAIMER: FOR RESEARCH USE ONLY. This product is a laboratory reagent intended strictly for in-vitro research and development. It is not for human consumption, veterinary use, or therapeutic application. Bodily introduction of any kind is strictly prohibited by law.
