Fat Burning Research Stack
Retatrutide + 5-Amino-1MQ + Cardarine (GW501516)
$330.00
Fat Burning Research Stack
Retatrutide + 5-Amino-1MQ + Cardarine (GW501516)
The 4Balance Codex: The Tri-Vector Metabolic Oxidation Matrix. Hormonal, Enzymatic, and Nuclear Modulation.
Product Overview
The Fat Burning Research Stack is a curated, high-performance research bundle designed for "systems-style" metabolic investigation. It provides researchers with the necessary tools to modulate energy expenditure, adipose biology, and mitochondrial function across three distinct physiological layers:
Hormonal: Triple-receptor agonism (GLP-1/GIP/Glucagon).
Enzymatic: NNMT inhibition for NAD+ optimization.
Nuclear/Transcriptional: PPARδ activation for fatty acid oxidation.
This stack is intended for advanced in vitro and preclinical models exploring the synergistic upper limits of lipolysis, thermogenesis, and substrate utilization.
Bundle Composition
This stack includes the following research compounds:
1× Retatrutide (LY3437943) – 10mg Vial
2× 5-Amino-1MQ – 5mg Vials (10mg Total)
1× Cardarine (GW501516) – 10mg Tablets (100 Count Bottle)
Component Mechanisms & Research Applications
1. Retatrutide (10mg) – The Hormonal Driver
Class: Triple-Hormone Receptor Agonist (GLP-1 / GIP / Glucagon)
Mechanism: Retatrutide is the premier tool for investigating "triple synergy." By engaging the Glucagon receptor alongside GLP-1 and GIP, it drives significant energy expenditure and thermogenesis often absent in mono- or dual-agonist models.
Research Focus: Hepatic lipid metabolism, adipose tissue browning, and glucose-dependent insulin secretion.
2. 5-Amino-1MQ (2× 5mg) – The Cellular Optimizer
Class: Selective NNMT Inhibitor
Mechanism: Blocks the enzyme Nicotinamide N-methyltransferase (NNMT), preventing the waste of NAD+ precursors. This inhibition is studied for its ability to correct "metabolic inflexibility" in adipocytes and restore mitochondrial efficiency.
Research Focus: Increasing intracellular NAD+ availability, reducing lipogenesis, and enhancing cellular metabolic rate without central nervous system stimulation.
3. Cardarine (GW501516) – The Oxidative Engine
Class: PPARδ Agonist (Nuclear Receptor Ligand)
Format: 10mg Laboratory Research Tablets (100 count)
Mechanism: Acts directly on the Peroxisome Proliferator-Activated Receptor Delta (PPARδ) to transcriptionally switch cells toward fatty acid oxidation. It effectively "reprograms" skeletal muscle fibers to burn fat as a primary fuel source.
Research Focus: Mitochondrial biogenesis, endurance adaptations, and the shift from glucose to lipid substrate utilization.
The Synergy: Why This Combination?
In the 4Balance Research Array, this stack allows investigators to map the entire metabolic cascade:
Signal: Retatrutide provides the systemic neuroendocrine signal to mobilize fuel and increase burn rate.
Efficiency: 5-Amino-1MQ ensures the cellular machinery (NAD+ levels) is optimized to handle increased metabolic demand.
Oxidation: Cardarine activates the nuclear transcription factors necessary to physically burn the mobilized fatty acids in the mitochondria.
Key Literature References
Jastreboff, A. M., et al. (2023). Triple-Hormone-Receptor Agonist Retatrutide for Obesity — A Phase 2 Trial. New England Journal of Medicine.
Knerr, P. J., et al. (2024). Next generation GLP-1/GIP/glucagon triple agonists... Cell Metabolism.
Neelakantan, H., et al. (2019). Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase... Biochemical Pharmacology.
Narkar, V. A., et al. (2008). AMPK and PPARdelta agonists are exercise mimetics. Cell.
DISCLAIMER: FOR LABORATORY RESEARCH USE ONLY. These products are laboratory reagents intended strictly for in-vitro and preclinical research. They are not drugs, food additives, or dietary supplements. NOT for human or veterinary use, consumption, or therapeutic application. The Cardarine tablets are for laboratory dosing convenience only and are not for oral consumption by humans. Buyer confirms they are a qualified researcher familiar with the safety protocols required for handling these compounds.
