GHRP-6 (Growth Hormone Releasing Peptide-6)

Available in 5mg & 10mg Lyophilized Vials

The Potent Ghrelin Mimetic | First-Generation Secretagogue

The 4Balance Codex: The High-Flux Growth Hormone Agonist with Systemic Metabolic Engagement.

Product Overview

GHRP-6 is a synthetic hexapeptide (chain of 6 amino acids) and one of the original Growth Hormone Secretagogues (GHS) developed. Unlike later generations that sought to isolate GH release from other metabolic signals, GHRP-6 acts as a broad-spectrum ghrelin mimetic.

This unique property makes it a critical research tool. It stimulates a massive pulse of Growth Hormone (GH) while simultaneously engaging the "hunger hormone" pathways. We provide this compound in 5mg and 10mg vials for research protocols investigating rapid mass accretion, appetite stimulation in wasting models, and cytoprotection.

Mechanism of Action: The Ghrelin Vector

GHRP-6 operates through a dual-pathway mechanism that distinguishes it from selective agents like Ipamorelin:

1. GHS-R1a Activation: It binds strongly to the Growth Hormone Secretagogue Receptor (GHS-R1a) in the anterior pituitary, triggering a substantial release of stored growth hormone. This pulse mimics the body's natural "hunger-driven" GH spikes.

2. Ghrelin Mimicry (Appetite Stimulation): GHRP-6 binds to receptors in the hypothalamus that regulate energy balance, signaling a state of "energy deficit." In research subjects, this results in a profound increase in gastric motility and appetite.

3. Somatostatin Inhibition: It indirectly assists GH release by inhibiting the release of somatostatin (the hormone that "turns off" GH production), clearing the path for maximum pituitary output.

Primary Research Applications

In the 4Balance Research Array, GHRP-6 is utilized when "selective" GH release is not enough, and a broader metabolic response is required.

• Cachexia & Wasting Models: Due to its potent ability to stimulate appetite (orexigenic effect), GHRP-6 is the primary peptide for researching treatments for sarcopenia, frailty, and cachexia (muscle wasting) where increased caloric intake is essential.

• Rapid Tissue Repair: Investigated for its ability to accelerate healing in non-union fractures and soft tissue injuries via the upregulation of IGF-1.

• Cytoprotection: Unique among secretagogues, GHRP-6 has been shown in studies to possess direct cardioprotective and neuroprotective properties, potentially reducing cellular damage during ischemic events (lack of oxygen).

• Combination Protocols: Frequently stacked with GHRH analogues (like CJC-1295) to investigate the synergistic amplification of the GH pulse.

Technical Specifications

• Compound Name: GHRP-6 (Growth Hormone Releasing Peptide-6)

• Sequence: His-D-Trp-Ala-Trp-D-Phe-Lys-NH2

• Available Sizes: 5mg Vial / 10mg Vial

• Format: Lyophilized Powder

• Purity: ≥99% (HPLC Verified)

• Solubility: Water Soluble (Requires Bacteriostatic Water for reconstitution).

• Storage: Store lyophilized at -20°C. Reconstituted peptide should be kept at 4°C.

DISCLAIMER: FOR LABORATORY RESEARCH USE ONLY. This product is a laboratory reagent intended strictly for in-vitro and in-vivo research and development. It is not for human consumption, veterinary use, or therapeutic application. This product is not a drug, food, or dietary supplement. Bodily introduction of any kind is strictly prohibited by law. Buyer assumes all responsibility for applicable regulations and appropriate use in a research setting.