IGF-1 LR3 (Long R3 Insulin-like Growth Factor-1)
Available in 100mcg & 1mg Lyophilized Vials
$200.00
IGF-1 LR3 (Long R3 Insulin-like Growth Factor-1)
Available Formats:
1mg Lyophilized Vial (Single)
100mcg Lyophilized Vials (Bundle of 10)
The Extended-Release Hyperplastic Agent | Potent Growth Factor Analogue
The 4Balance Codex: The Cellular Multiplier. Sustained Bioavailability for Hyperplasia and Nutrient Partitioning.
Product Overview
IGF-1 LR3 is a synthetic, modified analogue of human Insulin-like Growth Factor-1. It is structurally engineered with two critical alterations: the substitution of Arginine with Glutamic Acid at position 3, and an extension of 13 amino acids at the N-terminus.
These modifications completely alter the peptide's pharmacokinetics, creating a compound that is approximately 3x more potent than standard IGF-1.
We offer two distinct formats to suit your research protocols:
1mg Single Vial: Ideal for high-volume stock solutions and extended research series.
100mcg Kit (10 Vials): Designed for precise, single-application assays where maintaining maximal stability and preventing degradation of reconstituted stock is a priority.
Mechanism of Action: The "Binding Protein" Evasion
The primary limitation of native IGF-1 is that it is rapidly bound and neutralized by IGF Binding Proteins (IGFBPs) in the bloodstream, leading to a biologically active half-life of less than 20 minutes. IGF-1 LR3 is engineered to overcome this limit:
IGFBP Evasion: The specific amino acid modifications significantly reduce IGF-1 LR3's affinity for binding proteins. This allows the peptide to remain free, biologically active, and available to saturate cellular receptors.
Extended Half-Life: Because it avoids neutralization, IGF-1 LR3 remains bioactive for approximately 20–30 hours. This provides a sustained window of signaling rather than a fleeting pulse.
Hyperplasia Signaling: While Growth Hormone induces hypertrophy (cell size increase), IGF-1 LR3 is the primary driver of hyperplasia—the proliferation and splitting of cells to create new muscle fibers and tissue structures.
Primary Research Applications
In the 4Balance Research Array, IGF-1 LR3 is the gold standard for studies involving cellular proliferation and metabolic efficiency.
Myogenesis & Tissue Repair: Investigating the proliferation of satellite cells and the formation of new myofibers in skeletal muscle tissue.
Nutrient Partitioning: IGF-1 LR3 acts similarly to insulin by shuttling amino acids and glucose into muscle cells. However, unlike insulin, it promotes lipolysis (fat loss) rather than lipogenesis (fat storage), making it a key subject in body recomposition research.
Cellular Survival: Studied for its potent anti-apoptotic (anti-cell death) properties in neural and cardiac tissues under oxidative stress.
Technical Specifications
Compound Name: Long R3 IGF-1 (Recombinant)
Sequence Length: 83 Amino Acids
Molecular Weight: 9111.0 Da
Purity: ≥99% (HPLC Verified)
Format: Lyophilized Powder
Solubility: Soluble in Acetic Acid or Bacteriostatic Water. (Note: Acetic Acid is often preferred for initial dissolution of high-concentration stock to ensure stability before further dilution).
Storage: Store lyophilized at -20°C.
DISCLAIMER: FOR LABORATORY RESEARCH USE ONLY. This product is a laboratory reagent intended strictly for in-vitro and in-vivo research and development. It is not for human consumption, veterinary use, body-building, or therapeutic application. This product is not a drug, food, or dietary supplement. Bodily introduction of any kind is strictly prohibited by law. Buyer assumes all responsibility for applicable regulations and appropriate use in a research setting.
