Kisspeptin

Available in 5mg & 10mg Lyophilized Vials

The HPG Axis Initiator | The Endogenous Signal Restorer

The 4Balance Codex: The Upstream Regulator. Activation of the GnRH cascade for native Testosterone and Fertility signaling.

Product Overview

Kisspeptin-10 is a synthetic fragment of the naturally occurring Kisspeptin protein (encoded by the KiSS-1 gene). In neuroendocrinology, it is recognized as the "Gatekeeper of Reproduction." Unlike exogenous hormones that replace natural production, Kisspeptin acts directly on the hypothalamus to initiate the body's own hormonal cascades.

We provide this critical signaling peptide in two research-grade formats:

• 5mg Vial: For standard HPG axis investigations.

• 10mg Vial: High-concentration format for extended protocols or multi-subject studies.

Mechanism of Action: The Upstream Cascade

Kisspeptin-10 operates at the very top of the hormonal hierarchy, offering a mechanism distinct from TRT or HCG:

1. Hypothalamic Activation: It binds to the GPR54 (Kiss1R) receptor in the hypothalamus, stimulating the secretion of Gonadotropin-Releasing Hormone (GnRH).

2. The Pituitary Response: This GnRH pulse signals the anterior pituitary gland to release Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH).

3. Endogenous Production: These hormones travel to the gonads to stimulate the natural production of Testosterone and support spermatogenesis (fertility).

4. Preservation of Function: Because it stimulates the entire axis rather than bypassing it, Kisspeptin is researched for its ability to maintain testicular size and function, preventing the atrophy associated with exogenous hormone administration.

Primary Research Applications

In the 4Balance Research Array, Kisspeptin-10 is the primary tool for studying HPG axis restoration:

• Hypogonadism & Axis Recovery: Investigating the "restart" of natural testosterone production following suppression (e.g., Post-Cycle Therapy models).

• Fertility & Spermatogenesis: Studies focusing on the role of FSH stimulation in maintaining sperm quality and motility.

• Metabolic Regulation: Emerging research links Kisspeptin signaling to the regulation of metabolism and energy balance, suggesting a link between reproductive health and body composition.

Technical Specifications

• Compound Name: Kisspeptin-10 (Kp-10)

• Sequence: Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2

• Available Sizes: 5mg Vial / 10mg Vial

• Format: Lyophilized Powder

• Purity: ≥99% (HPLC Verified)

• Solubility: Water Soluble (Requires Bacteriostatic Water).

• Storage: Store lyophilized at -20°C. Protect from light.

DISCLAIMER: FOR LABORATORY RESEARCH USE ONLY. This product is a laboratory reagent intended strictly for in-vitro and in-vivo research and development. It is not a drug, dietary supplement, or treatment for any medical condition. NOT for human consumption, veterinary use, or therapeutic application. Bodily introduction of any kind is strictly prohibited by law. Buyer assumes all responsibility for applicable regulations and appropriate use in a research setting.