KPV (Lysine-Proline-Valine)

Available in 5mg & 10mg Lyophilized Vials

The Anti-Inflammatory Tripeptide | Master Regulator of the Microbiome

The 4Balance Codex: The Targeted Modulator. Potent Antimicrobial and Anti-Inflammatory Action without Hormonal Side Effects.

Product Overview

KPV is a naturally occurring tripeptide fragment (C-terminal) of the hormone alpha-Melanocyte Stimulating Hormone (α-MSH). While full-length α-MSH has potent effects, it also carries pigmentary and hormonal activity. KPV isolates the specific anti-inflammatory and antimicrobial segments of the hormone, making it a highly targeted tool for research.

We offer this specialized peptide in two research-grade formats:

• 5mg Vial: For targeted dermatological or topical formulation research.

• 10mg Vial: High-concentration format for systemic or gastrointestinal inflammation studies.

Mechanism of Action: The NF-κB Inhibitor

KPV exerts its effects through a non-hormonal pathway that is distinct from steroids or NSAIDs:

1. Inflammation Control: KPV enters the cell and interacts directly with the nucleus to inhibit the NF-κB pathway—the primary "switch" for inflammatory responses. By turning this switch off, KPV can drastically reduce the production of pro-inflammatory cytokines.

2. Antimicrobial Defense: KPV has demonstrated significant antimicrobial activity against specific pathogens (including S. aureus and C. albicans). It is unique in its ability to combat infection while simultaneously reducing the inflammation caused by the infection.

3. No Pigmentation: Unlike its parent molecule α-MSH, KPV does not bind significantly to melanocortin receptors responsible for skin darkening, allowing for "clean" therapeutic modeling.

Primary Research Applications

In the 4Balance Research Array, KPV is a versatile agent used in models involving barrier tissue health:

• Gastrointestinal Health (IBD): Extensively researched for its ability to reduce inflammation in the gut lining (mucosa), making it a key compound for studying Ulcerative Colitis and Irritable Bowel Disease (IBD).

• Dermatology & Psoriasis: KPV is a staple in skin research. It is investigated for treating psoriasis, eczema, and dermatitis due to its ability to calm hyperactive immune responses in the skin.

• Wound Healing: Studies show KPV can accelerate wound closure and reduce scar formation by modulating the inflammatory phase of healing.

• Systemic Inflammation: Used as a general anti-inflammatory agent in models where steroidal side effects must be avoided.

Technical Specifications

• Compound Name: KPV (Lysine-Proline-Valine)

• Sequence: Lys-Pro-Val

• Available Sizes: 5mg Vial / 10mg Vial

• Format: Lyophilized Powder

• Purity: ≥99% (HPLC Verified)

• Solubility: Water Soluble.

• Storage: Store lyophilized at -20°C. Protect from light.

DISCLAIMER: FOR LABORATORY RESEARCH USE ONLY. This product is a laboratory reagent intended strictly for in-vitro and in-vivo research and development. It is not a drug, dietary supplement, or treatment for any medical condition. NOT for human consumption, veterinary use, or therapeutic application. Bodily introduction of any kind is strictly prohibited by law. Buyer assumes all responsibility for applicable regulations and appropriate use in a research setting.