MK-677 (Ibutamoren)

Available in 10mg Tablets (100 Count Bottle)

The Orally Active Growth Hormone Secretagogue | The Non-Peptide Ghrelin Mimetic

The 4Balance Codex: The Endogenous Amplifier. A potent, non-peptide small molecule that stimulates the pituitary's natural, pulsatile release of Growth Hormone and sustained elevation of systemic IGF-1 by mimicking the action of ghrelin.

Product Overview

Ibutamoren (MK-677) is a premier research agent in the class of Growth Hormone Secretagogues (GHS). It represents a significant breakthrough in neuroendocrinology research as a potent, orally active, non-peptide agonist of the ghrelin receptor.

Unlike traditional Growth Hormone Releasing Hormone (GHRH) peptides that require injection and possess short half-lives, MK-677 is a stable small molecule with high oral bioavailability and a substantial biological half-life of approximately 24 hours. 4Balance Peptides offers this foundational compound in precise, laboratory-grade 10mg tablets, allowing for consistent, easy administration in long-term research protocols without the variability inherent in liquid measuring.

Mechanism of Action: The Ghrelin Pathway

MK-677’s mechanism is distinct from exogenous HGH or traditional anabolic agents. It works by utilizing the body's natural pathways to amplify endogenous production:

1. Ghrelin Receptor Agonism: MK-677 acts as a selective agonist of the ghrelin/growth hormone secretagogue receptor (GHS-R1a). By mimicking the hunger hormone ghrelin, it binds to receptors in the hypothalamus and the anterior pituitary gland.

2. Pulsatile GH Stimulation: This binding stimulates the pituitary gland to secrete Growth Hormone (GH) in a natural, pulsatile manner. Research has demonstrated that daily oral administration can significantly increase basal GH levels.

3. Sustained IGF-1 Elevation: The elevation in GH leads to a significant, sustained downstream increase in serum Insulin-like Growth Factor 1 (IGF-1). Clinical studies have shown MK-677 capable of restoring IGF-1 levels in older subjects to those observed in healthy young adults, generally without a significant increase in circulating cortisol.

Primary Research Applications

In the 4Balance Research Array, MK-677 is the definitive oral agent for studies focused on the GH/IGF-1 axis:

• Lean Tissue Preservation & Anabolism: Investigating its ability to reverse diet-induced nitrogen wasting and increase fat-free mass (FFM), making it a primary agent in research regarding sarcopenia (age-related muscle loss) and catabolic states.

• Sleep Architecture & Recovery: Researching its profound impact on sleep quality. Studies indicate MK-677 can increase the duration of both REM and deep slow-wave sleep stages, which are crucial for neurological and physical recovery.

• Bone Mineral Density: Long-term studies evaluate its effects on increasing bone turnover and improving bone mineral density through the IGF-1 pathway.

• Appetite Regulation: Due to its ghrelin-mimicking properties, it is used in models studying appetite stimulation and metabolic energy balance.

Technical Specifications

• Compound Name: Ibutamoren Mesylate (MK-677)

• Format: Oral Tablets

• Concentration: 10mg per Tablet

• Quantity: 100 Tablets

• Purity: ≥99% (HPLC Verified)

• Half-Life: ~24 Hours

• Storage: Store at room temperature, away from direct light and moisture.

DISCLAIMER: FOR LABORATORY RESEARCH USE ONLY. This product is a laboratory chemical intended strictly for in-vitro and in-vivo research and development. It is not a drug, dietary supplement, or treatment for any medical condition. NOT for human consumption, veterinary use, or therapeutic application. Bodily introduction of any kind is strictly prohibited by law. Buyer assumes all responsibility for applicable regulations and appropriate use in a research setting.