MOTS-c (Mitochondrial-Derived Peptide)

Available in 10mg & 40mg Lyophilized Vials

The Exercise Mimetic | Mitochondrial-Nuclear Signal Transducer

The 4Balance Codex: The Metabolic Master Switch. Systemic Regulation of Glucose and Fatty Acid Oxidation via AMPK Activation.

Product Overview

MOTS-c (Mitochondrial ORF of the Twelve-S c) is a 16-amino acid peptide that represents a breakthrough in metabolic science. Unlike most peptides which are encoded by nuclear DNA, MOTS-c is encoded in the mitochondria. It functions as a signaling messenger, translocating from the mitochondria to the nucleus to regulate genetic expression in response to metabolic stress.

We offer this advanced metabolic agent in two formats to suit your research scale:

• 10mg Vial: For pilot studies and standard metabolic assays.

• 40mg Vial: A high-capacity format designed for extended dosing protocols, given that MOTS-c research often requires higher milligram-based concentrations compared to other peptides.

Mechanism of Action: The "Exercise Mimetic"

MOTS-c is frequently categorized in literature as an "exercise mimetic" because it induces physiological responses similar to physical training, even in sedentary models.

1. AMPK Activation: MOTS-c targets the folate-methionine cycle, leading to an increase in AICAR levels, which subsequently activates AMPK (Adenosine Monophosphate-activated Protein Kinase). AMPK is known as the cell's "master metabolic switch," turning on energy production and turning off energy storage.

2. Glucose Regulation: It promotes the uptake of glucose into muscle cells via a pathway distinct from insulin. Research indicates it can improve insulin sensitivity and prevent age-dependent and diet-induced insulin resistance.

3. Fatty Acid Oxidation: By influencing the nuclear genome, MOTS-c upregulates genes involved in the beta-oxidation of fatty acids, effectively shifting the body's substrate preference toward burning fat.

Primary Research Applications

In the 4Balance Research Array, MOTS-c is the primary tool for investigating metabolic flexibility and mitochondrial health.

• Obesity & Metabolic Syndrome: Investigating the prevention of diet-induced obesity and the reversal of insulin resistance.

• Physical Performance: Studies focusing on endurance capacity and the "training effect" at the cellular level without physical exertion.

• Longevity & Senescence: Research indicates MOTS-c levels decline with age. Supplementation is studied for its potential to restore youthful metabolic profiles and extend healthspan (notably linked to populations of Japanese centenarians).

• Bone Density: Emerging research suggests MOTS-c may promote the differentiation of osteoblasts (bone-forming cells).

Technical Specifications

• Compound Name: MOTS-c (Mitochondrial ORF of the Twelve-S c)

• Sequence: Met-Arg-Trp-Qln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg

• Available Sizes: 10mg / 40mg

• Format: Lyophilized Powder

• Purity: ≥99% (HPLC Verified)

• Solubility: Water Soluble (Requires Bacteriostatic Water).

• Storage: Store lyophilized at -20°C. Protect from light.

DISCLAIMER: FOR LABORATORY RESEARCH USE ONLY. This product is a laboratory reagent intended strictly for in-vitro and in-vivo research and development. It is not a drug, dietary supplement, or treatment for any medical condition. NOT for human consumption, veterinary use, or therapeutic application. Bodily introduction of any kind is strictly prohibited by law. Buyer assumes all responsibility for applicable regulations and appropriate use in a research setting.