Melanotan 1 (Afamelanotide)

Available in 5mg Lyophilized Vials

The Selective Photoprotective Agent | Linear Alpha-MSH Analogue

The 4Balance Codex: The Solar Shield. Targeted Eumelanogenesis for UV Protection without Non-Specific CNS Activation.

Product Overview

Melanotan 1 (also known as Afamelanotide) is a synthetic, linear analogue of the naturally occurring peptide alpha-Melanocyte Stimulating Hormone (α-MSH).

Unlike its circular counterpart (Melanotan 2), Melanotan 1 is highly selective. It is designed to mimic the body's natural tanning mechanism with high specificity for the melanocortin-1 receptor (MC1R). We offer this compound in 5mg research vials for studies focused on photoprotection and melanogenesis without the central nervous system side effects (such as arousal or appetite suppression) often seen in less selective analogues.

Mechanism of Action: Targeted Eumelanogenesis

Melanotan 1 operates through a specific receptor pathway to induce "physiological tanning" independent of UV damage:

1. MC1R Agonism: It binds directly to the melanocortin-1 receptors on the surface of melanocytes (pigment cells).

2. Eumelanin Production: This binding signals the cell to produce eumelanin, the dark pigment responsible for protecting DNA from ultraviolet radiation. Unlike sun exposure, which damages cells to trigger this response, Melanotan 1 initiates the protective mechanism chemically.

3. High Selectivity: The linear structure of Melanotan 1 ensures it binds primarily to skin receptors (MC1R) rather than brain receptors (MC3R/MC4R). This avoids the nausea, flushing, and sexual stimulation associated with non-selective variants.

Primary Research Applications

In the 4Balance Research Array, Melanotan 1 is the reference standard for photoprotection research:

• UV Defense & Photoprotection: Investigating the peptide's ability to build a "biological shield" against UV radiation, reducing the risk of burns and DNA damage.

• Photodermatoses: Used in research models for conditions involving extreme light sensitivity, such as Erythropoietic Protoporphyria (EPP) and solar urticaria.

• Skin Pigmentation Studies: Examining the regulation of skin tone and the treatment of hypopigmentation disorders (e.g., vitiligo) in a controlled setting.

Technical Specifications

• Compound Name: Melanotan 1 (Afamelanotide)

• Chemical Structure: Linear peptide; [Nle4, D-Phe7]-α-MSH

• Sequence: Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2

• Available Size: 5mg Vial

• Format: Lyophilized Powder

• Purity: ≥99% (HPLC Verified)

• Solubility: Water Soluble (Requires Bacteriostatic Water).

• Storage: Store lyophilized at -20°C. Protect from light.

DISCLAIMER: FOR LABORATORY RESEARCH USE ONLY. This product is a laboratory reagent intended strictly for in-vitro and in-vivo research and development. It is not a cosmetic, drug, dietary supplement, or tanning product. NOT for human consumption, veterinary use, or therapeutic application. Bodily introduction of any kind is strictly prohibited by law. Buyer assumes all responsibility for applicable regulations and appropriate use in a research setting.