Peri-Menopause Essentials Research Stack

Combination Kit: Oral Tablets & Lyophilized Peptides

Advanced Metabolic & Structural Support Protocol | The Hormonal Transition Defense

The 4Balance Codex: The Chronobiological & Metabolic Intercept. A quadruple-vector approach designed to modulate the profound physiological shifts associated with hormonal decline: fighting metabolic slowdown, preserving musculoskeletal integrity, and resetting neuro-endocrine rhythms.

Product Overview

The transition into non-reproductive states (peri-menopause) is characterized in research models by a cascade of physiological disruptions: a sharp decline in metabolic rate, accelerated loss of bone mineral density (osteopenia), reduction in lean muscle mass (sarcopenia), and significant disruption of circadian sleep cycles.

The 4Balance Peri-Menopause Essentials Stack is an advanced research protocol designed to counteract these specific mechanisms. This kit goes beyond traditional approaches by integrating Retatrutide, the newest generation triple-hormone metabolic agonist, alongside foundational structural and neuro-endocrine regulators. This synergy allows researchers to investigate a comprehensive defense against the aging processes accelerated by hormonal shifts.

Mechanism of Action: The Quadruple Defense Synergy

This research stack targets four critical pathways that become dysregulated during hormonal transition states.

1. The Advanced Metabolic Reset (Retatrutide - 10mg Vial)

The decline in estrogen is strongly linked to metabolic slowdown and visceral adipose accumulation. Retatrutide, a GIP/GLP-1/Glucagon receptor triple agonist, is included to model a profound systemic metabolic correction. Research indicates its ability to aggressively improve insulin sensitivity, normalize lipid metabolism, and increase energy expenditure via glucagon signaling, far exceeding older single-receptor agonists.

2. Musculoskeletal Integrity (Ostarine MK-2866 - 25mg Tablets)

The loss of estrogen is a primary driver of bone density loss and muscle atrophy. Ostarine acts as a selective anabolic signal to preserve structural tissue. In research settings, it is investigated for its ability to bind selectively to androgen receptors in bone and muscle, mitigating catabolism without the side effects of traditional hormone therapies.

3. Neuro-Endocrine & Sleep Optimization (MK-677 - 10mg Tablets)

Sleep fragmentation is a hallmark of peri-menopause, deeply affecting systemic recovery. MK-677, a long-acting ghrelin mimetic, restores the amplitude of endogenous Growth Hormone and IGF-1 pulsatility. This pathway is critical for deep-wave sleep architecture, cognitive recovery, and maintaining skin and connective tissue elasticity.

4. Cellular Aging & Circadian Rhythm (Epitalon - 10mg Vial)

Hormonal chaos often desynchronizes the body's biological clock. Epitalon is a synthetic pineal gland peptide. It is researched for its dual ability to upregulate telomerase activity (addressing cellular aging) and normalize melatonin production in the pineal gland, helping to reset circadian rhythms and restore restorative sleep patterns.

Primary Research Applications

In the 4Balance Research Array, this comprehensive stack is utilized for:

• Metabolic Adaptation Models: Investigating the reversal of hormonally induced visceral fat gain and insulin resistance using triple-agonist therapy.

• Bone & Muscle Preservation: Studying the preventative effects of selective androgen receptor signaling on bone mineral density loss during estrogen deficiency.

• Chronobiology & Recovery: Measuring improvements in sleep architecture and recovery markers in subjects with disrupted circadian rhythms.

Technical Specifications & Kit Contents

This research kit combines precise oral dosing formats with high-purity injectable peptides for a multi-modal administration protocol.

Oral Components (Research Tablets):

• Ostarine (MK-2866): 25mg Tablets (100 Count Bottle) | Structural Support

• MK-677 (Ibutamoren): 10mg Tablets (100 Count Bottle) | GH/Sleep Support

Lyophilized Peptide Components (Injectable Vials):

• Retatrutide (Triple Agonist): One (1) 10mg Vial | Metabolic Reset

• Epitalon (Pineal Peptide): Four (4) 10mg Vial | Cellular/Circadian Support

All components are ≥99% Purity (HPLC Verified).

DISCLAIMER: FOR LABORATORY RESEARCH USE ONLY. This product is a large combination of laboratory research chemicals intended strictly for in-vitro and in-vivo research and development. These products are not drugs, dietary supplements, or treatments for any medical condition (including menopause or osteoporosis in humans). NOT for human consumption, veterinary use, or therapeutic application. Bodily introduction of any kind is strictly prohibited by law. Buyer assumes all responsibility for applicable regulations and appropriate use in a research setting.

Scientific Context & References for Research Pathways: [1] New England Journal of Medicine (2023). "Retatrutide, a GIP, GLP-1, and Glucagon Receptor Agonist, for People with Obesity." (Demonstrating profound metabolic effects of triple agonism). [2] Journal of Cachexia, Sarcopenia and Muscle (2011). "Selective androgen receptor modulators in preclinical and clinical development." (Discussing tissue selectivity for muscle/bone preservation). [3] Journal of Clinical Endocrinology & Metabolism (1996). "Treatment of obese subjects with the oral growth hormone secretagogue MK-677 increases serum insulin-like growth factor I and alters markers of bone turnover." [4] Neuroendocrinology Letters (2003). "The pineal gland and the circadian neuroendocrine regulation of the aging process. Correction with peptide bioregulators." (Research on Epitalon and circadian rhythms).