PNC-27

Available in 5mg & 10mg Lyophilized Vials

The Selective Oncolytic Agent | HDM-2 Membrane Targeter

The 4Balance Codex: The Membrane Disruptor. Targeted Lysis of Malignant Cells via HDM-2 Binding.

Product Overview

PNC-27 is a synthetic, 32-amino acid fusion peptide designed for advanced oncolytic research. It combines a specific sequence derived from the p53 protein with a membrane-penetrating domain. PNC-27 is heavily researched for its remarkable ability to selectively kill cancer cells while leaving healthy cells unharmed.

4Balance Peptides provides this specialized research agent in two formats:

• 5mg Vial: For standard in-vitro cytotoxicity assays.

• 10mg Vial: High-concentration format for extended research protocols.

Mechanism of Action: Selective Pore Formation

PNC-27 operates through a unique, membrane-active mechanism that exploits specific protein expression on the surface of malignant cells:

1. HDM-2 Targeting: The peptide is designed to bind specifically to the HDM-2 protein. While HDM-2 is typically found inside cells, it is abnormally expressed on the membranes of various cancer cells.

2. Transmembrane Pores: Upon binding to membrane-bound HDM-2, PNC-27 inserts itself into the cancer cell membrane. This insertion creates transmembrane pores.

3. Selective Lysis: These pores compromise membrane integrity, causing the malignant cell to rupture (lysis) and undergo necrosis. Because healthy cells do not express HDM-2 on their membranes, they are not targeted by PNC-27, resulting in high selectivity.

Primary Research Applications

In the 4Balance Research Array, PNC-27 is a critical tool for oncology and membrane biophysics:

• Targeted Cancer Therapy Models: Investigating novel approaches to destroying solid tumor cells that express membrane HDM-2.

• Selective Cytotoxicity: Researching agents that offer potent anticancer activity without the untoward side effects on normal, healthy tissue often associated with traditional chemotherapy.

• p53 Pathway Research: Studying peptide derivatives of the p53 protein and their interaction with regulatory proteins like HDM-2.

Technical Specifications

• Compound Name: PNC-27

• Sequence Length: 32 Amino Acids

• Available Sizes: 5mg / 10mg

• Format: Lyophilized Powder

• Purity: ≥99% (HPLC Verified)

• Solubility: Water Soluble (Requires Bacteriostatic Water).

• Storage: Store lyophilized at -20°C. Protect from light.

DISCLAIMER: FOR LABORATORY RESEARCH USE ONLY. This product is a laboratory reagent intended strictly for in-vitro and in-vivo research and development. It is not a drug, dietary supplement, or treatment for any medical condition. NOT for human consumption, veterinary use, or therapeutic application. Bodily introduction of any kind is strictly prohibited by law. Buyer assumes all responsibility for applicable regulations and appropriate use in a research setting.