PT-141 (Bremelanotide)

Available in 10mg Lyophilized Vials

The Central Arousal Agent | The Neuro-Melanocortin Agonist

The 4Balance Codex: The CNS Modulator. Initiating Arousal Signaling via Hypothalamic Melanocortin Activation.

Product Overview

PT-141 (Bremelanotide) is a synthetic, cyclic peptide analogue of alpha-Melanocyte Stimulating Hormone (α-MSH). It represents a significant departure from traditional agents used in sexual dysfunction research.

Unlike PDE5 inhibitors (such as sildenafil) which act on the vascular system to facilitate blood flow, PT-141 acts directly on the central nervous system (CNS) to initiate the neural signals for arousal. 4Balance Peptides offers this potent neuro-modulator in a high-concentration 10mg vial, designed for advanced research into the neurobiology of desire and physiological arousal responses.

Mechanism of Action: The Central Signal

PT-141's mechanism is unique because it bypasses peripheral vascular pathways to trigger arousal centrally:

1. Melanocortin Receptor Agonism: PT-141 is a non-selective agonist that binds with high affinity to melanocortin receptors, specifically MC3R and MC4R, which are densely located in the hypothalamus of the brain.

2. Hypothalamic Activation: By activating these neural pathways, PT-141 modulates brain activity related to sexual desire and motivation. In research models, it is shown to induce arousal in both males (erectile response) and females (solicitation behavior) by generating the neurological "signal" for arousal, rather than just facilitating the physical mechanics.

Primary Research Applications

In the 4Balance Research Array, PT-141 is the premier tool for investigating centrally-mediated arousal:

• Sexual Dysfunction Models: Extensively researched for its efficacy in models of male erectile dysfunction (ED) and female hypoactive sexual desire disorder (HSDD), particularly in cases unresponsive to vascular-acting agents.

• Neurobiology of Libido: Used to map the specific hypothalamic pathways and receptor interactions governing sexual motivation and behavior.

• Hemorrhagic Shock & Ischemia: Due to its broad melanocortin activity, PT-141 is also investigated for potential protective effects in models of reperfusion injury and circulatory shock.

Technical Specifications

• Compound Name: PT-141 (Bremelanotide Acetate)

• Chemical Structure: Cyclic heptapeptide lactam analogue of α-MSH

• Sequence: Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH

• Available Size: 10mg Vial

• Format: Lyophilized Powder

• Purity: ≥99% (HPLC Verified)

• Solubility: Water Soluble (Requires Bacteriostatic Water).

• Storage: Store lyophilized at -20°C. Protect from light.

DISCLAIMER: FOR LABORATORY RESEARCH USE ONLY. This product is a laboratory reagent intended strictly for in-vitro and in-vivo research and development. It is not a drug, dietary supplement, or treatment for any medical condition. NOT for human consumption, veterinary use, or therapeutic application. Bodily introduction of any kind is strictly prohibited by law. Buyer assumes all responsibility for applicable regulations and appropriate use in a research setting.