PT-141 & Melanotan 2 Research Stack

Available in 10mg + 10mg Lyophilized Combination Kit

The Dual Melanocortin Agonist Stack | Synergistic CNS Arousal & Pigmentation Signaling

The 4Balance Codex: The Comprehensive Melanocortin Assay. Simultaneous, high-potency activation of hypothalamic arousal pathways (MC3R/MC4R) and dermal melanogenesis (MC1R).

Product Overview

This exclusive research stack combines two potent, cyclic analogues of alpha-Melanocyte Stimulating Hormone (α-MSH): PT-141 (Bremelanotide) and Melanotan 2 (MT-2).

While both peptides influence the melanocortin system, they offer distinct yet complementary pharmacodynamic profiles. This combination kit is designed for advanced researchers investigating the complex interplay between centrally-mediated sexual arousal signaling and peripheral pigmentation pathways. We provide these agents in two separate 10mg vials to allow for precise, independent titration or combined administration protocols.

Mechanism of Action: Synergistic Agonism

The research value of this stack lies in its broad-spectrum, high-affinity agonism across the melanocortin receptor family:

1. PT-141 (The Central Specialist): PT-141 is unique in that it acts specifically on the central nervous system (CNS) to initiate the neural cascade for sexual motivation and desire. It primarily targets MC3R and MC4R receptors in the hypothalamus, bypassing vascular pathways to generate arousal centrally in both male and female models.

2. Melanotan 2 (The Systemic Multi-Agonist): MT-2 is a non-selective agonist. It potently stimulates dermal MC1R receptors (driving intense eumelanin production/pigmentation) while concurrently reinforcing CNS arousal and suppressing appetite via MC3R/MC4R activation.

3. The Synergy: By combining the focused CNS activity of PT-141 with the potent, broad-spectrum activity of MT-2, researchers can model simultaneous, maximal stimulation of neuro-arousal and melanogenesis pathways.

Primary Research Applications

In the 4Balance Research Array, this stack is utilized for multi-parametric studies:

• Complex Arousal Models: Investigating resistant cases of hypoactive sexual desire and erectile dysfunction by targeting hypothalamic pathways with dual agonists for a compounded effect.

• Melanogenesis & Photoprotection: Studying the mechanisms of maximal eumelanin synthesis for skin pigmentation and UV-defense models.

• Neuroendocrine Regulation: Exploring the overlapping hypothalamic pathways governing energy homeostasis (appetite suppression) and reproductive behavior influenced by strong MC4R activation.

Technical Specifications

• Kit Contents: Two (2) separate lyophilized vials.

• Vial 1 Compound: PT-141 (Bremelanotide) Acetate — 10mg

• Vial 2 Compound: Melanotan 2 (MT-2) Acetate — 10mg

• Format: Lyophilized Powder

• Purity: ≥99% (HPLC Verified)

• Solubility: Water Soluble (Requires Bacteriostatic Water for reconstitution).

• Storage: Store lyophilized at -20°C. Protect from light.

DISCLAIMER: FOR LABORATORY RESEARCH USE ONLY. This product is a laboratory reagent combination intended strictly for in-vitro and in-vivo research and development. These products are not drugs, dietary supplements, or treatments for any medical condition. NOT for human consumption, veterinary use, cosmetic use, or therapeutic application. Bodily introduction of any kind is strictly prohibited by law. Buyer assumes all responsibility for applicable regulations and appropriate use in a research setting.