Selank

Available in 5mg & 11mg Lyophilized Vials

The Non-Sedating Anxiolytic | The Neuroprotective Nootropic Peptide

The 4Balance Codex: The Cognitive Stabilizer. A synthetic regulatory peptide that enhances stress resilience, improves memory focus, and alleviates anxiety through non-GABAergic pathways and BDNF upregulation.

Product Overview

Selank is a synthetic heptapeptide and a structural analogue of the endogenous immunomodulatory peptide, Tuftsin. It was developed at the Institute of Molecular Genetics of the Russian Academy of Sciences with the specific goal of creating a potent anxiolytic (anti-anxiety) agent devoid of the sedating side effects and addictive potential common to benzodiazepines.

Selank is unique in clinical research for its ability to simultaneously reduce anxiety and stress levels while improving cognitive functions like memory, learning capacity, and focus. 4Balance Peptides offers this versatile compound in two convenient research formats: a 5mg vial for standard assays and a high-content 11mg vial for extended or intensive research protocols.

Mechanism of Action: Novel Neuro-Modulation

Selank’s mechanism is distinct from traditional CNS depressants. It does not bind to GABA-A receptors, which explains its lack of sedative or withdrawal effects. Instead, its activity is multimodal:

1. Monoamine Neurotransmitter Regulation: Research indicates that Selank modulates the metabolism of critical neurotransmitters—specifically serotonin, dopamine, and norepinephrine—in key brain regions involved in mood and stress response, such as the hypothalamus and hippocampus. It appears to stabilize the turnover rate of these chemicals under stress conditions.

2. BDNF Upregulation (Neuroplasticity): A critical mechanism for its nootropic effects is its influence on neurotrophins. Studies suggest Selank increases the expression of Brain-Derived Neurotrophic Factor (BDNF) in the hippocampus. BDNF is essential for neuroplasticity, the growth of new neurons, and the formation of long-term memory.

3. Enkephalinase Inhibition: Selank has been shown to inhibit enzymes that degrade endogenous enkephalins (the brain's natural opioids). By prolonging the half-life of these natural stress-relieving peptides, Selank enhances the body's inherent resilience to stress.

Primary Research Applications

In the 4Balance Research Array, Selank is a premier agent for studies focused on the intersection of mood, stress, and cognition:

• Anxiety & Stress Disorders: Investigating its efficacy in models of Generalized Anxiety Disorder (GAD), social anxiety, and acute stress reactions without causing psychomotor slowing.

• Cognitive Enhancement (Nootropic): Studying improvements in memory consolidation, attention span, and learning ability, particularly in fatigued or stressed subjects.

• Neuroprotection & Restoration: Due to its BDNF-elevating properties, it is researched for potential protective effects against neuronal damage and support in recovery from ischemic conditions.

• Immunomodulation: Exploring its inherited ability from Tuftsin to modulate inflammatory responses, particularly those exacerbated by chronic psychological stress.

Technical Specifications

• Compound Name: Selank Acetate

• Sequence: Thr-Lys-Pro-Arg-Pro-Gly-Pro (TKPRPGP)

• Molecular Formula: C₃₃H₅₇N₁₁O₉

• Molar Mass: 751.9 g/mol

• Available Sizes: 5mg / 11mg

• Format: Lyophilized Powder

• Purity: ≥99% (HPLC Verified)

• Solubility: Water Soluble (Requires Bacteriostatic Water).

• Storage: Store lyophilized at -20°C. Protect from light.

DISCLAIMER: FOR LABORATORY RESEARCH USE ONLY. This product is a laboratory reagent intended strictly for in-vitro and in-vivo research and development. It is not a drug, dietary supplement, or treatment for any medical condition. NOT for human consumption, veterinary use, or therapeutic application. Bodily introduction of any kind is strictly prohibited by law. Buyer assumes all responsibility for applicable regulations and appropriate use in a research setting.