Semax

Available in 5mg & 11mg Lyophilized Vials

The Advanced Nootropic Heptapeptide | BDNF & NGF Upregulator

The 4Balance Codex: The Neurogenic Accelerator. A synthetic ACTH analogue engineered to rapidly upregulate neurotrophic factors (BDNF/NGF), enhancing cognitive resilience, memory consolidation, and neuroprotection under duress.

Product Overview

Semax is one of the most extensively researched cognitive-enhancing peptides globally. It is a synthetic heptapeptide derived from the N-terminus of the endogenous hormone ACTH (Adrenocorticotropic hormone). Specifically, it is an analogue of the ACTH(4-10) fragment, stabilized by the addition of a tripeptide Pro-Gly-Pro C-terminus sequence to prevent enzymatic degradation.

Crucially, while derived from ACTH, Semax lacks hormonal activity and does not stimulate the adrenal glands. 4Balance Peptides offers this potent neuro-regulator in two distinct research formats: a standard 5mg vial and a high-concentration 11mg vial for intensive research protocols demanding higher concentrations.

Mechanism of Action: Rapid Neurotrophin Induction

Semax’s primary value in research stems from its rapid and multifaceted impact on brain physiology, distinct from traditional stimulants:

1. Upregulation of Neurotrophic Factors: The most significant mechanism of Semax is its ability to rapidly increase the expression of Brain-Derived Neurotrophic Factor (BDNF) and Nerve Growth Factor (NGF) in the hippocampus and frontal cortex. These proteins are essential drivers of neuroplasticity, neuronal survival, and the growth of new synapses (synaptogenesis), which form the biological basis of learning and memory.

2. Modulation of Neurotransmitters: Semax influences the metabolism and turnover rate of key neurotransmitters, particularly dopamine and serotonin. This action is believed to underlie its ability to improve mood stabilization and enhance focus without the excitotoxicity or "crash" associated with amphetamine-like compounds.

3. Neuroprotection via Stress Reduction: By modulating the brain's response to stress and reducing oxidative damage during states of ischemia (low oxygen), Semax exerts a significant neuroprotective effect, preserving neuronal integrity under challenging conditions.

Primary Research Applications

In the 4Balance Research Array, Semax is the definitive tool for studies focused on enhancing cognitive architecture:

• Cognitive Enhancement & Nootropics: Investigating improvements in attention span, complex problem-solving speed, and memory consolidation, particularly in models of fatigue or high cognitive demand.

• Neuroprotection & Stroke Recovery: Extensively studied for its therapeutic potential following ischemic stroke or transient ischemic attacks due to its ability to protect neurons from hypoxia and inflammation.

• Stress Resilience & Mood: Exploring its application in models of anxiety, depression, and ADHD, focusing on its capacity to stabilize neurotransmitter levels and mitigate the effects of chronic stress on the brain.

• Ophthalmologic Research: Investigating its protective effects on the optic nerve in models of glaucoma and optic neuropathy.

Technical Specifications

• Compound Name: Semax Acetate

• Sequence: Met-Glu-His-Phe-Pro-Gly-Pro (MEHFPGP)

• Molecular Formula: C₃₇H₅₁N₉O₁₀S

• Molar Mass: 813.9 g/mol

• Available Sizes: 5mg / 11mg

• Format: Lyophilized Powder

• Purity: ≥99% (HPLC Verified)

• Solubility: Water Soluble (Requires Bacteriostatic Water).

• Storage: Store lyophilized at -20°C. Protect from light.

DISCLAIMER: FOR LABORATORY RESEARCH USE ONLY. This product is a laboratory reagent intended strictly for in-vitro and in-vivo research and development. It is not a drug, dietary supplement, or treatment for any medical condition. NOT for human consumption, veterinary use, or therapeutic application. Bodily introduction of any kind is strictly prohibited by law. Buyer assumes all responsibility for applicable regulations and appropriate use in a research setting.