SLU-PP-332

Available in 5mg Lyophilized Vials

The Metabolic "Exercise Mimetic" | Novel ERRα Agonist

The 4Balance Codex: The Mitochondrial Igniter. A potent, synthetic small molecule that acts as a selective Estrogen-Related Receptor Alpha (ERRα) agonist, simulating the metabolic and transcriptional effects of endurance exercise without systemic hormonal activity.

Product Overview

SLU-PP-332 is at the forefront of metabolic research. It is not a traditional peptide, but a novel synthetic small molecule designed to act as an "exercise mimetic."

While many compounds attempt to increase metabolism via stimulation (increasing heart rate or anxiety), SLU-PP-332 works via a completely distinct pathway. It is designed to trick skeletal muscle and adipose tissue into a state of high metabolic demand, mimicking the effects of chronic endurance training. 4Balance Peptides offers this cutting-edge compound in a 5mg format for advanced metabolic investigations.

Mechanism of Action: Selective ERRα Agonism

SLU-PP-332’s mechanism is unique and the subject of intense current study. It functions as a selective agonist for Estrogen-Related Receptor Alpha (ERRα).

Despite the name, ERRα does not bind to estrogen. It is a nuclear receptor highly expressed in metabolically active tissues (muscles, heart, brain) that governs the transcription of genes related to mitochondrial function and energy usage.

1. Mitochondrial Biogenesis & Fatty Acid Oxidation: By activating ERRα, SLU-PP-332 signals cells to increase the creation of new mitochondria (the cell's power plants). Furthermore, it shifts the body's preferred fuel source away from glucose and toward the oxidation (burning) of fatty acids. Research models suggest this can lead to increased energy expenditure even at rest.

2. Enhanced Endurance Phenotype: Studies in murine models have shown that administration of SLU-PP-332 can significantly increase treadmill running distance and time to exhaustion in sedentary subjects, effectively conferring an "endurance athlete" metabolic profile without actual training.

3. Adipose Tissue Remodeling (Beiging): Research indicates that ERRα activation can promote the "beiging" of white adipose tissue. This transforms energy-storing white fat into metabolically active beige fat, which is capable of thermogenesis (burning calories as heat).

4. Muscle Preservation during Weight Loss: Unlike many metabolic agents that cause catabolism (muscle loss) alongside fat loss, SLU-PP-332 appears to preserve lean muscle mass in research models during periods of caloric deficit or significant body weight reduction.

Primary Research Applications

In the 4Balance Research Array, SLU-PP-332 is utilized for studies focused on metabolic dysfunction and physical performance:

• Obesity & Metabolic Syndrome: Investigating its potential to reverse diet-induced obesity and improve metabolic parameters independent of changes in food intake.

• Exercise Mimetics: Studying the molecular pathways of exercise adaptation in sedentary models or models where physical exercise is impossible.

• Muscle Wasting Conditions: Exploring its potential to maintain muscle function and mass in aging (sarcopenia) or immobilization models.

Technical Specifications & Solubility Note

• Compound Name: SLU-PP-332

• Format: Lyophilized Powder

• Quantity: 5mg per Vial

• Purity: ≥99% (HPLC Verified)

• Storage: Store lyophilized at -20°C. Protect from light.

• Solubility Alert: Researchers should note that SLU-PP-332 is a hydrophobic molecule with poor water solubility. Standard reconstitution with simple bacteriostatic water is often ineffective for in-vivo research protocols. Successful dissolution typically requires specialized co-solvent systems (e.g., involving DMSO, PEG, or similar agents) depending on the specific research application.

DISCLAIMER: FOR LABORATORY RESEARCH USE ONLY. This product is a laboratory research chemical intended strictly for in-vitro and in-vivo research and development. It is not a drug, dietary supplement, or treatment for any medical condition. NOT for human consumption, veterinary use, or therapeutic application. Bodily introduction of any kind is strictly prohibited by law. Buyer assumes all responsibility for applicable regulations, proper handling, and appropriate use in a research setting.