SLU-PP-332

Available in 250mcg Tablets (100 Count Bottle)

The Oral Exercise Mimetic | Selective ERRα Agonist & Mitochondrial Activator

The 4Balance Codex: The Metabolic Igniter. A novel, orally bioavailable synthetic small molecule that acts as a selective agonist for Estrogen-Related Receptor Alpha (ERRα). By activating this specific nuclear receptor, it simulates the transcriptional and metabolic effects of endurance exercise, driving mitochondrial biogenesis and favoring fatty acid oxidation.

Product Overview

SLU-PP-332 is at the forefront of metabolic research, categorized as a potent "exercise mimetic." Unlike traditional stimulants that upregulate metabolism via the central nervous system (often causing increased heart rate or anxiety), SLU-PP-332 works directly at the cellular level in skeletal muscle.

It is designed to trick the body's tissues into a state of high metabolic demand, mimicking the physiological adaptations of chronic endurance training even in sedentary states. 4Balance Peptides offers this cutting-edge compound in precise 250mcg tablets, providing researchers with a stable, convenient, and highly accurate method for oral administration in metabolic and endurance protocols.

Mechanism of Action: The ERRα Pathway

SLU-PP-332 is not a peptide; it is a synthetic small molecule specifically engineered to be orally bioavailable. Its mechanism is unique and the subject of intense current study:

1. Selective ERRα Agonism: SLU-PP-332 binds selectively to Estrogen-Related Receptor Alpha (ERRα). Despite the name, ERRα does not bind to estrogen; it is an "orphan nuclear receptor" highly expressed in tissues with high energy demands (like the heart and skeletal muscle). ERRα governs the transcription of genes related to mitochondrial function and energy usage.

2. Mitochondrial Biogenesis & Function: By activating ERRα, SLU-PP-332 signals skeletal muscle cells to increase the creation of new mitochondria (mitochondrial biogenesis) and improve the efficiency of the electron transport chain. This simulates the cellular remodeling that occurs in response to regular aerobic exercise.

3. Metabolic Substrate Shift (Fat Oxidation): Research indicates that SLU-PP-332 shifts the body's preferred fuel source. It upregulates genes involved in lipid catabolism (fat burning) and downregulates glucose utilization. In pre-clinical models, this leads to increased energy expenditure and fat loss even at rest, without alterations in food intake or physical activity levels.

4. Enhanced Endurance Phenotype: A hallmark finding in research (notably studies led by Elgendy et al.) is that administration of SLU-PP-332 significantly increases running distance and time-to-exhaustion in murine models, effectively conferring an "endurance athlete" metabolic profile without prior training.

Primary Research Applications

In the 4Balance Research Array, SLU-PP-332 is utilized for studies focused on metabolic dysfunction and physical performance markers:

• Metabolic Syndrome & Obesity: Investigating its potential to reverse diet-induced obesity, improve insulin sensitivity, and combat fatty liver disease by increasing basal metabolic rate.

• Exercise Physiology Mimetics: Studying the molecular pathways of exercise adaptation in sedentary models or models where physical activity is restricted (e.g., aging or immobilization).

• Muscle Preservation: Exploring its potential to maintain lean muscle mass and function during periods of caloric deficit or catabolism.

Technical Specifications

• Compound Name: SLU-PP-332

• Format: Oral Tablets

• Concentration: 250mcg per Tablet

• Quantity: 100 Tablets

• Purity: ≥99% (HPLC Verified)

• Mechanism: Selective ERRα Agonist

• Storage: Store at room temperature, away from direct light and moisture.

DISCLAIMER: FOR LABORATORY RESEARCH USE ONLY. This product is a laboratory chemical intended strictly for in-vitro and in-vivo research and development. It is not a drug, dietary supplement, or treatment for any medical condition. NOT for human consumption, veterinary use, or therapeutic application. Bodily introduction of any kind is strictly prohibited by law. Buyer assumes all responsibility for applicable regulations and appropriate use in a research setting.