SS-31
Available in 10mg & 50mg Lyophilized Vials
$90.00
SS-31 (Elamipretide) Mitochondrial Peptide
Available in 10mg & 50mg Lyophilized Vials
The Inner Mitochondrial Membrane Stabilizer | Targeting the Root of Cellular Energy
The 4Balance Codex: The Mitochondrial Architect. A cell-permeable tetrapeptide that selectively targets the inner mitochondrial membrane, binding to cardiolipin to restore cristae structure, optimize electron transport chain efficiency, and reduce ROS leakage at the source.
Product Overview
SS-31, also widely known in research literature as Elamipretide or Bendavia, is a pioneering peptide in the field of mitochondrial medicine. It represents a distinct approach to cellular health that moves beyond traditional antioxidants.
While standard antioxidants attempt to "mop up" reactive oxygen species (ROS) after they have been produced, SS-31 is designed to prevent their formation in the first place. It is an aromatic-cationic tetrapeptide engineered to penetrate cell membranes and concentrate specifically within the inner mitochondrial membrane (IMM). 4Balance Peptides offers this sophisticated research agent in 10mg for standard protocols and high-concentration 50mg vials for intensive metabolic studies.
Mechanism of Action: The Cardiolipin Connection
SS-31’s mechanism is unique and highly specific. Its therapeutic potential in research models stems from its interaction with Cardiolipin, a unique phospholipid found almost exclusively in the inner mitochondrial membrane.
Restoring Mitochondrial Architecture: Cardiolipin is essential for maintaining the curvature of mitochondrial cristae (the folds of the inner membrane). During aging or metabolic stress, cardiolipin becomes oxidized and damaged, causing these folds to flatten. SS-31 binds selectively to cardiolipin, stabilizing its structure and helping to restore the necessary curvature of the cristae.
Optimizing the Electron Transport Chain (ETC): The protein complexes of the ETC require cardiolipin to organize into "supercomplexes" for efficient energy transfer. By stabilizing cardiolipin, SS-31 tightens these complexes. Research indicates this improves the efficiency of ATP (cellular energy) production.
Preventing ROS Leakage at the Source: When ETC complexes are loosely organized due to damaged cardiolipin, electrons "leak" out, creating harmful Reactive Oxygen Species (ROS) – the primary driver of oxidative stress. SS-31 does not scavenge existing ROS; instead, by tightening the ETC, it dramatically reduces electron leakage, stopping oxidative stress at its origin point.
Primary Research Applications
Because mitochondrial dysfunction is a hallmark of numerous conditions, SS-31 is utilized across a broad spectrum of research disciplines:
Aging and Sarcopenia Models: Investigating the revitalization of aged mitochondria in skeletal muscle and heart tissue to reverse age-related energetic decline.
Cardiovascular Research: Extensively studied in models of ischemia-reperfusion injury and heart failure for its ability to protect myocardial mitochondria during stress events.
Renal/Kidney Health: Research suggests SS-31 may protect against acute kidney injury and diabetic nephropathy by preserving mitochondrial structure in renal cells.
Metabolic Disorders: Exploring its role in improving cellular bioenergetics in models of insulin resistance and metabolic syndrome.
Technical Specifications
Compound Name: SS-31 / Elamipretide / Bendavia
Sequence: D-Arg-Tyr(2,6-dimethyl)-Lys-Phe-NH2
Molecular Formula: C₃₂H₄₉N₉O₅
Molar Mass: 639.8 g/mol
Available Sizes: 10mg / 50mg vials
Format: Lyophilized Powder
Purity: ≥99% (HPLC Verified)
Solubility: Water Soluble (Requires Bacteriostatic Water).
Storage: Store lyophilized at -20°C. Protect from light.
DISCLAIMER: FOR LABORATORY RESEARCH USE ONLY. This product is a laboratory reagent intended strictly for in-vitro and in-vivo research and development. It is not a drug, dietary supplement, or treatment for any medical condition. NOT for human consumption, veterinary use, or therapeutic application. Bodily introduction of any kind is strictly prohibited by law. Buyer assumes all responsibility for applicable regulations and appropriate use in a research setting.
