TB-500
Available in 5mg & 10mg Lyophilized Vials
$80.00
TB-500 (Thymosin Beta-4)
Available in 5mg & 10mg Lyophilized Vials
The Cellular Migration Architect | Systemic Tissue Repair & Angiogenesis
The 4Balance Codex: The Actin Regulator. A synthetic analogue of the ubiquitous, naturally occurring protein Thymosin β4. It governs the actin cytoskeleton to promote rapid cell migration to injury sites, drives therapeutic angiogenesis, and downregulates inflammatory cytokines to accelerate regenerative processes.
Product Overview
TB-500 is a synthetic version of Thymosin Beta-4 (Tβ4), a 43-amino acid peptide that is ubiquitous in almost all human cells and found in high concentrations in blood platelets, wound fluid, and other tissues involved in healing.
Unlike growth factors that stimulate cellular division, TB-500’s primary role in research is regulating cellular movement (migration). It is considered one of the premiere research agents for investigating soft tissue repair, inflammation modulation, and cytoprotection. 4Balance Peptides offers this essential compound in standard 5mg vials and high-concentration 10mg vials for demanding research protocols.
Mechanism of Action: The Actin Cytoskeleton & Beyond
TB-500’s multifaceted mechanism acts as a "first responder" signal to damaged tissue. Its primary mode of action involves the regulation of actin, the most abundant protein in eukaryotic cells.
Actin Sequestration & Cell Migration: The ability of a cell to move to a wound site depends on its internal "skeleton" rapidly assembling and disassembling actin filaments. TB-500 binds to monomeric actin (G-actin), creating a pool of available building blocks. When a cell needs to move to injured tissue, TB-500 releases this actin, allowing for rapid polymerization and accelerated cell migration toward the injury.
Therapeutic Angiogenesis: Research indicates that TB-500 is a potent angiogenic factor. It promotes the migration and differentiation of endothelial cells, leading to the formation of new blood vessels. This is critical for delivering oxygen and nutrients necessary for tissue repair at ischemic (low oxygen) injury sites.
Modulation of Inflammation & Fibrosis: TB-500 does not just suppress inflammation; it modulates it. Studies show it can downregulate pro-inflammatory cytokines while upregulating anti-inflammatory pathways. Furthermore, it has been researched for its ability to reduce excessive fibrosis (scar tissue formation) during the healing process, promoting more functional tissue regeneration.
Cytoprotection & Anti-Apoptosis: In models of severe stress (such as cardiac ischemia or neurotoxicity), TB-500 has demonstrated the ability to inhibit apoptosis (programmed cell death), preserving tissue viability under duress.
Primary Research Applications
Because it is fundamental to the basic healing machinery of the cell, TB-500 is utilized across a diverse range of research disciplines:
Musculoskeletal Repair: Extensively studied in models of tendon, ligament, and muscle injury for speeding up recovery times and improving the tensile strength of healed tissue.
Cardiovascular Research: Investigated for its potential to repair heart tissue and promote neovascularization following myocardial infarction (heart attack).
Dermatological Healing: Used in research for accelerating the closure of acute wounds, treating diabetic ulcers, and minimizing scar formation in skin incisions.
Corneal Repair: Due to its gentle nature and potent migratory effects, it is researched for healing injuries to the surface of the eye.
Technical Specifications
Compound Name: Thymosin Beta-4 (TB-500)
Sequence: Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-ILe-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-ILe-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser-OH
Molecular Formula: C₂₁₂H₃₅₀N₅₆O₇₈S
Molar Mass: 4963.5 g/mol
Available Sizes: 5mg / 10mg vials
Format: Lyophilized Powder
Purity: ≥99% (HPLC Verified)
Solubility: Water Soluble (Requires Bacteriostatic Water).
Storage: Store lyophilized at -20°C. Protect from light.
DISCLAIMER: FOR LABORATORY RESEARCH USE ONLY. This product is a laboratory reagent intended strictly for in-vitro and in-vivo research and development. It is not a drug, dietary supplement, or treatment for any medical condition. NOT for human consumption, veterinary use, or therapeutic application. Bodily introduction of any kind is strictly prohibited by law. Buyer assumes all responsibility for applicable regulations and appropriate use in a research setting.
