L-Glutathione – 1500mg
High-Potency Master Antioxidant | Cellular Redox Regulator
$100.00
L-Glutathione – 1500mg
High-Potency Master Antioxidant | Cellular Redox Regulator
The 4Balance Codex: The Central Axis of Cellular Defense and Detoxification.
Product Overview
L-Glutathione (GSH) is a naturally occurring tripeptide comprised of three amino acids: glutamate, cysteine, and glycine. It is ubiquitously recognized in biochemistry as the body’s "Master Antioxidant."
While standard research protocols often utilize lower concentrations (600mg), 4Balance Peptides offers a High-Flux 1500mg lyophilized vial. This ultra-high concentration is designed for advanced research applications requiring substantial antioxidant loads to investigate cellular defense mechanisms, hepatic detoxification pathways, and tyrosinase inhibition kinetics.
Mechanism of Action: The Redox Anchor
Glutathione exists in cells in two states: reduced (GSH) and oxidized (GSSG). This product provides the bioactive Reduced form.
Oxidative Stress Neutralization: The thiol group in cysteine acts as a reducing agent, directly neutralizing reactive oxygen species (ROS) and free radicals (superoxide, hydroxyl radicals). It is essential for maintaining the intracellular redox state and preventing cellular damage.
Detoxification Conjugation: In hepatic (liver) models, Glutathione is the substrate for the enzyme Glutathione S-Transferase. It binds to toxins, heavy metals, and carcinogens, rendering them water-soluble for excretion.
Tyrosinase Inhibition (Pigmentation Research): L-Glutathione is a potent inhibitor of tyrosinase, the rate-limiting enzyme in melanin synthesis. Research indicates it shifts the melanogenesis pathway from eumelanin (dark pigment) toward pheomelanin (lighter pigment), making it a key compound in dermatological studies.
Primary Research Applications
The 1500mg concentration is specifically suited for:
Hepatic Health Models: Investigating the protective effects of high-dose GSH against hepatotoxicity, alcohol-induced damage, and fatty liver progression.
Dermatological Studies: Modeling the inhibition of melanogenesis and the reduction of hyperpigmentation at the cellular level.
Neuroprotection: Exploring the role of GSH depletion in neurodegenerative conditions (Parkinson’s/Alzheimer’s models) and the restorative capacity of exogenous supplementation.
Immune Cytology: Studying the proliferation of lymphocytes and the modulation of the immune response under oxidative stress.
Technical Specifications
Compound Name: L-Glutathione (Reduced)
Chemical Structure: γ-L-Glutamyl-L-cysteinyl-glycine
Total Mass: 1500mg (High Concentration)
Format: Sterile Lyophilized Powder
Purity: ≥99% (HPLC Verified)
Solubility: Water Soluble. Note: Due to the high mass (1500mg), ensure sufficient bacteriostatic water (typically 3ml+) is used for reconstitution to ensure complete dissolution.
Storage: Store lyophilized at -20°C. Protect from light (oxidation sensitive).
References
Pizzorno, J. (2014). Glutathione! Integrative Medicine.
Watanabe, F., et al. (2014). Skin-whitening and skin-condition-improving effects of topical oxidized glutathione: a double-blind and placebo-controlled clinical trial in healthy women. Clinical, Cosmetic and Investigational Dermatology.
Wu, G., et al. (2004). Glutathione metabolism and its implications for health. The Journal of Nutrition.
DISCLAIMER: FOR LABORATORY RESEARCH USE ONLY. This product is a laboratory reagent intended strictly for in-vitro and in-vivo research and development. It is not a dietary supplement, drug, or food product. It is strictly NOT approved for human consumption, medical treatment, or therapeutic application. Bodily introduction of any kind is prohibited by law. Buyer assumes all responsibility for applicable regulations and appropriate use in a research setting.
