Tesamorelin (Modified GHRH 1-44)

Available in 5mg & 10mg Lyophilized Vials

The Visceral Adiposity Targeting Agent | Stabilized GHRH Analogue

The 4Balance Codex: The Deep Fat Modulator. A synthetic, stabilized analogue of Growth Hormone-Releasing Hormone (GHRH) that stimulates pulsatile GH secretion. It is uniquely researched for its selective reduction of visceral adipose tissue (VAT) and investigation into improving cognitive function in aging models.

Product Overview

Tesamorelin is a synthetic peptide consisting of the 44 amino acid sequence of human Growth Hormone-Releasing Hormone (GHRH), modified with a trans-3-hexenoic acid group. This modification renders it more stable and resistant to enzymatic degradation than natural GHRH, significantly extending its half-life.

While many peptides influence growth hormone, Tesamorelin is distinct in clinical research for its highly specific impact on reducing visceral adipose tissue (VAT)—the metabolically dangerous "deep fat" that surrounds internal organs—particularly in lipodystrophy models. 4Balance Peptides offers this highly specialized agent in 5mg and high-concentration 10mg vials for advanced metabolic research.

Mechanism of Action: Targeted Lipolysis & Neuroprotection

Tesamorelin’s value in research stems from its stabilized structure and its downstream effects on specific tissue types:

1. Pulsatile Pituitary Stimulation: Like endogenous GHRH, Tesamorelin binds to receptors on anterior pituitary somatotrophs to stimulate Growth Hormone (GH) secretion. Crucially, it maintains the natural pulsatile rhythm of GH release, rather than the continuous elevation seen with exogenous HGH. This preserves the body’s natural negative feedback loops, maintaining a favorable safety profile in research settings.

2. Selective Visceral Fat Reduction: The subsequent rise in GH and IGF-1 triggers lipolysis (fat breakdown). Research indicates that visceral fat cells are significantly more sensitive to the lipolytic actions of GH than subcutaneous fat cells. Consequently, Tesamorelin administration in clinical studies has demonstrated profound reductions in visceral fat mass with lesser impacts on subcutaneous fat.

3. Cognitive & Neuro-Correlation: Emerging research (notably studies conducted at the University of Washington) has investigated Tesamorelin's effects on aging and cognition. Findings suggest it may improve executive function and verbal memory in older adults with mild cognitive impairment (MCI), potentially by modulating brain GABA levels and increasing CNS IGF-1 availability.

4. Metabolic Markers: By reducing metabolically active visceral fat, Tesamorelin research often correlates with improvements in secondary metabolic markers, such as reduced triglycerides and decreased systemic inflammation (C-reactive protein).

Primary Research Applications

In the 4Balance Research Array, Tesamorelin is the premier agent for studies focusing on specific fat depots and metabolic aging:

• Lipodystrophy & Metabolic Syndrome: Investigating the reduction of disproportionate abdominal fat accumulation and associated metabolic derangements.

• Visceral vs. Subcutaneous Adiposity: Comparative studies on how different fat depots respond to hormonal signaling.

• Cognitive Decline Models: Researching GHRH analogues as potential interventions for age-related cognitive impairment and neuroprotection.

• Cardiovascular Risk Markers: Studying the relationship between visceral fat reduction and improvements in lipid profiles and inflammatory markers.

Technical Specifications

• Compound Name: Tesamorelin Acetate (trans-3-hexenoyl-GHRH 1–44 amide)

• Sequence: trans-3-hexenoyl-[Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Gln-Gln-Gly-Glu-Ser-Asn-Gln-Glu-Arg-Gly-Ala-Arg-Ala-Arg-Leu]-NH2

• Molecular Formula: C₂₂₁H₃₆₆N₇₂O₆₇S

• Molar Mass: 5135.9 g/mol

• Available Sizes: 5mg / 10mg vials

• Format: Lyophilized Powder

• Purity: ≥99% (HPLC Verified)

• Solubility: Water Soluble (Requires Bacteriostatic Water).

• Storage: Store lyophilized at -20°C. Protect from light.

DISCLAIMER: FOR LABORATORY RESEARCH USE ONLY. This product is a laboratory reagent intended strictly for in-vitro and in-vivo research and development. It is not a drug, dietary supplement, or treatment for any medical condition. NOT for human consumption, veterinary use, or therapeutic application. Bodily introduction of any kind is strictly prohibited by law. Buyer assumes all responsibility for applicable regulations and appropriate use in a research setting.