VIP (Vasoactive Intestinal Peptide)

Available in 5mg & 10mg Lyophilized Vials

The Neuro-Immunological Regulator | Systemic Anti-Inflammation & Smooth Muscle Control

The 4Balance Codex: The Systemic Harmonizer. A ubiquitous 28-amino acid neuropeptide that functions as a critical signaling bridge between the central nervous system and the immune system, exerting potent anti-inflammatory effects and regulating smooth muscle tone across the gut-brain-lung axes.

Product Overview

Vasoactive Intestinal Peptide (VIP) is a 28-amino acid neuropeptide. While originally discovered in the intestinal tract (hence the name), decades of research have revealed it to be one of the most widespread signaling molecules in the body.

VIP is found extensively in the central nervous system (CNS), peripheral nerves, gastrointestinal tract, heart, lungs, and immune organs. It is considered a vital pleiotropic factor, meaning it influences multiple distinct physiological systems simultaneously. 4Balance Peptides offers this essential research agent in standard 5mg vials and high-concentration 10mg vials for diverse physiological and immunological protocols.

Mechanism of Action: The VPAC Receptor Pathway

VIP’s value in research lies in its ability to bind to two specific G-protein coupled receptors known as VPAC1 and VPAC2. Because these receptors are widely expressed throughout the body, VIP exerts profound effects in three key areas:

1. Potent Immune Modulation & Anti-Inflammation: This is perhaps the most significant area of modern VIP research. VIP acts as a powerful "brake" on inflammation. Research shows it shifts the immune response balance from a pro-inflammatory Th1 profile toward an anti-inflammatory Th2 profile. It actively inhibits the release of damaging pro-inflammatory cytokines (such as TNF-α, IL-6, and IL-12) from macrophages and dendritic cells, making it a key agent in studying autoimmune models.

2. Neuroprotection & Circadian Rhythm: In the CNS, VIP is crucial for protecting neurons from excitotoxicity, oxidative stress, and inflammation (neuroinflammation). Furthermore, VIP is highly concentrated in the suprachiasmatic nucleus (SCN) of the hypothalamus—the body’s "master clock"—where it plays an essential role in regulating circadian rhythms and sleep-wake cycles.

3. Smooth Muscle Regulation (Gut & Lung): True to its name, VIP is a primary neurotransmitter in the gut. It induces smooth muscle relaxation, regulating GI motility, sphincter function, and water/electrolyte secretion. Similarly, in the pulmonary system, VIP acts as a potent bronchodilator, relaxing airway smooth muscle.

Primary Research Applications

Because VPAC receptors are ubiquitous, VIP is utilized across a diverse range of high-impact research disciplines:

• Autoimmune & Inflammatory Disorders: Extensively investigated in models of rheumatoid arthritis, multiple sclerosis, and sepsis for its ability to downregulate systemic inflammation.

• Neurodegenerative Disease: Studied for its neuroprotective properties in models of Parkinson’s and Alzheimer’s disease, specifically targeting neuroinflammation.

• Gastrointestinal Health (IBS/IBD): Researching its role in maintaining gut barrier integrity, regulating motility, and calming gut inflammation in colitis models.

• Pulmonary Research: Investigated as a bronchodilator in asthma and COPD models, and for its ability to mitigate lung fibrosis.

Technical Specifications

• Compound Name: Vasoactive Intestinal Peptide (VIP)

• Sequence: His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH2

• Molecular Formula: C₁₄₇H₂₃₈N₄₄O₄₂S

• Molar Mass: 3325.8 g/mol

• Available Sizes: 5mg / 10mg vials

• Format: Lyophilized Powder

• Purity: ≥99% (HPLC Verified)

• Solubility: Water Soluble (Requires Bacteriostatic Water).

• Storage: Store lyophilized at -20°C. Protect from light.

DISCLAIMER: FOR LABORATORY RESEARCH USE ONLY. This product is a laboratory reagent intended strictly for in-vitro and in-vivo research and development. It is not a drug, dietary supplement, or treatment for any medical condition. NOT for human consumption, veterinary use, or therapeutic application. Bodily introduction of any kind is strictly prohibited by law. Buyer assumes all responsibility for applicable regulations and appropriate use in a research setting.